Table 1.
Study inclusion criteria.
Fig 1.
Flowsheet of the study selection process according to PRISMA guidelines.
Table 2.
Baseline characteristics of included studies.
Percentages represent the proportion of patients in each study with the given characteristic. Values are given for all study participants, not exclusively those who had major bleeds.
Fig 2.
Relative Odds of Fatal Bleeding Given Occurrence of Major Bleed.
Odds ratios and 95% confidence intervals are given for the relative odds that major bleeding events will lead to fatal bleeding events.
Fig 3.
Relative Odds for fatal bleeding in treatment indication subgroups.
Odds ratios and 95% confidence intervals are given for the relative odds that major bleeding events will lead to fatal bleeding events. Subgroups are determined by the indication for anticoagulation and fall into two categories, treatment of acute venous thromboembolism or stroke prophylaxis in atrial fibrillation.
Fig 4.
Relative odds of fatal bleeding given patient with intracranial bleeding event.
Odds ratios and 95% confidence intervals are given for the relative odds that intracranial bleeding events will lead to fatal bleeding events.
Fig 5.
Relative odds of fatal bleeding given patient with major extracranial bleeding event.
Odds ratios and 95% confidence intervals are given for the relative odds that major extracranial bleeding events will lead to fatal bleeding events.