Table 1.
Demographic and Hematologic Characteristics.
Fig 1.
Relationship of ARC or Hemoglobin with HbF According to Age Group.
A-C: Correlation of HbF and ARC in patients with SCA who are less than 1 year of age, 1–9 years of age and 10–20 years old, respectively. D-F: Correlation of HbF and hemoglobin in the same age groups, respectively. HbF% is on the x-axis in each panel. Correlation coefficients (r) and p- values are shown in each panel. ARC, Absolute Reticulocyte Count; Hb, hemoglobin. Each dot represents a steady state value for a separate patient.
Fig 2.
Relationship of ARC and F-cells by Age Group.
A. Correlation of F-cell % and ARC in infants with SCA (less than 1 year of age) at steady state. B. Same correlation with children with SCA who are between 1 and 9 years of age and C. between 10 and 20 years of age. ARC, Absolute Reticulocyte Count. Each dot represents a steady state value for a separate patient.
Fig 3.
Representative Flow Dot Plots for Pancellular vs. Heterocellular HbF Distribution.
A. Erythrocytes from a 3 month old infant with SCA stained with fluorescent antibodies against HbF, revealing a pancellular HbF distribution. B. Representative F-cell staining from an older child with SCA, representative of heterocellular HbF distribution.
Fig 4.
Comparison of F-cell and HbF levels in Infants and Children with ARC<200 K/μL and ARC ≥ 200K/μL.
A. F-cell level comparisons in infants less than 1 year of age and children between ages 1–9 years with an ARC < 200 K/μL (open bars) and ARC ≥ 200 K/μL (shaded bars) (*p = 6.2 E-5, **p = 1.7E-6). B. Comparison of HbF levels in infants and children ages 1–9 years and ARC < 200 K/μL (open bars) and ARC ≥ 200 K/μL (shaded bars) (*p = 2.2E-5,**p = 7.4E-7). Standard deviation bars are included.