Table 1.
Adapted START criteria for determination of cardiovascular medication underuse.
Table 2.
Baseline characteristics of the ESTHER subsample stratified for appropriate use and underuse according to START criteria.
Fig 1.
Presence of medication underuse was associated with frailty, BMI, and the number of drugs.
Selected model variables and their association with medication underuse in a multivariate logistic regression model (*** < 0.001; ** < 0.01; and * < 0.05).
Fig 2.
Medication underuse did not affect cardiovascular outcomes, but rather deaths due to non-cardiovascular causes.
(A) Kaplan-Meier plot of relevant cardiovascular events for appropriate use and medication underuse (P value calculated by the log-rank test). (B) cumulative incidence functions of relevant (black) and competing events (gray) according to status of medication underuse (P value calculated by the Gray test) (solid line: appropriate use; dotted line: underuse).
Table 3.
Hazard ratios resulting from competing risk Cox regression analysis based on cause-specific hazards for relevant events (fatal and non-fatal cardiovascular events) and competing events (non-cardiovascular deaths) in the ESTHER cohort after brown bag medication review.