Table 1.
Candidate CYP genes, alleles, polymorphisms identification and enzymatic activity.
Table 2.
Candidate CYP genes, corresponding predicted phenotype and enzymatic activity according to the allele combination (EM = normal metabolizers, IM and PM = decrease function, UM and UMH = increase function).
Table 3.
Demographic data of cases and controls subjects.
Table 4.
Clinical patterns of aromatic anticonvulsant-induced reactions and demographic characteristics (DRESS = Drug Reaction with eosinophilia and systemic symptoms, SJS = Stevens-Johnson Syndrome, MPE = Maculopapular exanthema, IgIV = Intravenous immunoglobulin).
Table 5.
Phenotipic frequencies for cytochrome P450 (CYP) 2C9, 2C19 and 3A5 in healthy controls, cases and tolerants (EM = normal metabolizers, IM and PM = decrease function, UM and UMH = increase function) as predicted by SNP genotype.
Fig 1.
Classification and regression tree: CYP3A5 phenotype discriminates between cases and tolerants (EM = normal metabolizers, IM and PM = decrease function, UM and UMH = increase function).