Table 1.
Demographic information for females in the control and PMS groups.
Fig 1.
The scores of Pre-VAS (the scores on the visual analog scales for stressful situations before the scanning) and Post-VAS (the scores on the visual analog scales for stressful situations before the scanning) for females in the control (N = 16) and PMS (premenstrual syndrome, N = 16) groups.
Table 2.
The scores (M±SD) of BAI and BDI for females in the control (N = 16) and PMS (N = 16) groups.
Fig 2.
The functional connectivity map of the DMN (default mode network).
Axial images show the network for the control (upper panel) and PMS (lower panel) groups. The statistical map was derived from a one-sample t-test of DMN components. The bar at the right shows the T-values. Images are in radiologic format with the left side of the image corresponding to the right side of the subject’s brain.
Fig 3.
Differences in the functional connectivity between the PMS and control groups.
The statistical map was derived from a two-sample t-test of DMN components. The red and blue color denote, respectively, the regions showing increased and decreased functional connectivity in the PMS compared with the controls. a, MTG/STG; b, PHG; c, MTG; d, precentralgyrus; e-g, MFG. The bar at the right shows T-values. Images are in radiologic format with the left side of the image corresponding to the right side of the subject’s brain.
Table 3.
Regions of DMN (default mode network) demonstrating altered functional connectivity in the PMS group.
Fig 4.
Correlation between the DMN connectivity and individual pre-VAS levels in the PMS group.
(A) The regions showing significant correlations with pre-VAS. a, cuneus; b/c, MFG. Images are in radiologic format with the left side of the image corresponding to the right side of the subject’s brain. t. Bar at the right shows correlation (r) values. (B) Scatter plots of the correlations between pre-VAS and mean functional connectivity values in the cuneus (center: -3, 84, 3;6mm-radius sphere) and MFG (center: -18, -18, 60; 6mm-radiussphere). Each circular dot represents the data from one participant. The regression line indicates a positive relationship between the connectivity and the pre-VAS.
Fig 5.
Correlation between DMN connectivity and individual BDI levels in the PMS group.
(A) The regions showing significant correlations with BDI.a, MTG; b, MFG; c, precuneus. Images are in radiologic format with the left side of the image corresponding to the right side of the brain. Bar at the right shows correlation (r) values. (B) Scatter plots of the correlations between BDI and functional connectivity. Each circular dot represents the data from one participant. The regression line indicates a relationship between the BDI scores and the mean connectivity values in the MTG (center: -45, -60, 27; 6mm-radius sphere), MFG (MNI center: -18, 18, 48; 6mm-radius sphere), and the precuneus (MNI center: 6, -3, 42; 6mm-radius sphere).
Table 4.
Regions showing significant connectivity-behavioral correlations in the PMS group.