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Fig 1.

Summary of study search and selection.

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Table 1.

Characteristics of studies included in the meta-analysis.

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Table 1 Expand

Table 2.

Descriptions of Asbestos Exposure and Smoking of Included Studies.

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Table 2 Expand

Table 3.

Descriptions of Outcome of Included Studies.

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Fig 2.

Random-effects meta-analysis of the synergistic effect between asbestos exposure and smoking cause lung cancer- Case control studies.

(A) Summary odds ratio of asbestos-exposed and non-smoking (A+S-) compared with not asbestos-exposed and non-smoking (A-S-). (B) Summary odds ratio of non-exposure to asbestos and smoking (A-S+) compared with not asbestos-exposed and non-smoking (A-S-). (C) Summary odds ratio of asbestos-exposed and smoking (A+S+) compared with not asbestos-exposed and non-smoking (A-S-).

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Table 4.

Effect of the Exposure to Asbestos (A) and/or Cigarette Smoking (S) on Lung Cancer Risk.

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Table 5.

Effect of the Exposure to Asbestos (A) and/or Cigarette Smoking (S) on Lung Cancer Risk in Case-Control Studies, Stratified by smoking levels.

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Table 5 Expand

Fig 3.

Random-effects meta-analysis of the synergistic effect between asbestos exposure and smoking cause lung cancer- Cohort study.

(A) Summary relative risk of asbestos-exposed and non-smoking (A+S-) compared with not asbestos-exposed and non-smoking (A-S-). (B) Summary relative risk of non-exposure to asbestos and smoking (A-S+) compared with not asbestos-exposed and non-smoking (A-S-). (C) Summary relative risk of asbestos-exposed and smoking (A+S+) compared with not asbestos-exposed and non-smoking (A-S-).

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Table 6.

Synergy and Multiplicative Indices between Asbestos Exposure and Cigarette Smoking.

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Table 6 Expand