Fig 1.
All data within NURSA are now readily accessible through nine sections within the homepage. Webpages within each NURSA section contain links to pertinent related data within NURSA 3.0, e.g., a Molecule Page will contain links to clinical trials within the Clinical section, and links to external online resources to allow end users to rapidly discover and explore information. Reprinted under a CC BY license, with permission from the Nuclear Receptor Signaling Atlas, original copyright 2015.
Fig 2.
On the All Molecules Page, end users can either browse nuclear receptors, coregulators and ligands, or narrow down the list of molecules using an Amazon-like filter module. In this example, the user enters the GO term “cell death” in the filter module to retrieve molecules mapping to that term. Reprinted under a CC BY license, with permission from the Nuclear Receptor Signaling Atlas, original copyright 2015.
Fig 3.
The Molecule Pages aggregate data from numerous external basic and clinical information resources, as well as public and NURSA-funded datasets, reagents and other entities. Reprinted under a CC BY license, with permission from the Nuclear Receptor Signaling Atlas, original copyright 2015.
Table 1.
Data points reflecting induction of the PIM1 oncogene by 17βE2 and by endocrine-disrupting chemicals targeting estrogenic pathways.
All data points predate the 2013 paper [15] describing PIM1 as a novel estrogen target gene. Accession ID: identifier in original parent archive; OE, overexpression; Veh, Vehicle.
Table 2.
Google Page Rank of selected biomedical research resources.