Table 1.
Neuropsychological Test Battery.
Fig 1.
Flow diagram of study participant status.
Middle column shows count data presented for total study membership; left shows valid neuropsychology assessment at each study time-point; and right are study exit events.
Table 2.
Demographic information for SVD cohort.
Table 3.
Longitudinal analysis of cognition in SVD.
Fig 2.
Estimates of annualized cognitive change cognitive indices.
Mean annualized cognitive change (filled circles) are displayed for the four key cognitive indices: Working Memory (WM), Episodic (Long-term) Memory (LTM), Processing Speed (PS) and Executive Function (EF). The composite Global change is also displayed. Error bars show the 95% confidence interval of the mean obtained from non-parametric bootstrap estimation. The dotted line represents stable performance. Significant change occurs where error bars do not cross the dotted line.
Fig 3.
Cognitive change for the four cognitive indices.
Rows present data for the four cognitive indices, from the top: 1st row–Executive Function, 2nd row–Processing Speed, 3rd row–Working Memory, 4th row–Episodic (long-term) memory. Left figures present ‘spaghetti-plots’ where the cognitive index scores at each assessment (circles) are presented with scores for each subject joined by lines. Middle column figures present the lines of best fit from the linear model. Right column figures show the annualized change measure: the trajectory of change over time from the linear model.
Table 4.
Cognitive change and sample size estimates for tasks and composite indices.