Fig 1.
Note: The salience network, defined using a seed in the rAI (right anterior insula), MNI coordinates (38, -22, 10). The default mode network, defined using a seed in the PCC (posterior cingulate cortex), MNI coordinates (1, -55, 17).
Table 1.
Sample characteristics.
Fig 2.
Group Differences in seed to voxel connectivity.
Note: Results show increased connectivity between the salience network (as defined by the right anterior insula seed region) and the medial prefrontal cortex in ultra high-risk youth relative to controls. Results are thresholded at the voxel-level at puncorrected <0.001 and then corrected at the cluster-level using a false-discovery rate (FDR) of p<0.05.
Table 2.
Resting state functional connectivity: regions and coordinates.
Fig 3.
Associations between connectivity and facial emotion recognition.
Note: Results indicate positive correlations (yellow) between the default mode network (defined by the posterior cingulate cortex as a seed region) and the somatosensory cortex (shown bilaterally) and the cerebellum among UHR individuals. An inverse relationship in signal (blue) between the default mode network with the precuneus is shown in the medial left hemisphere at the top. Results are thresholded at the voxel-level at puncorrected <0.001 and then corrected at the cluster-level using a false-discovery rate (FDR) of p<0.05.
Fig 4.
Associations between connectivity and social functioning.
Note: Results show a positive correlation between signal of the salience network (defined by the right anterior insula) and the occipital cortex. This relationship was different for controls and ultra-high risk youth (UHR). Connectivity associations were positive for the control group (shown above) and negative for UHR individuals. Results are thresholded at the voxel-level at puncorrected <0.001 and then corrected at the cluster-level using a false-discovery rate (FDR) of p<0.05.