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Fig 1.

Study protocol.

ICU length of stay ≥ 5 days, classifying patients according to the type of admission (percent of patients), followed by an evaluation of individual organ dysfunction/organ failure on ICU day three. ScS, scheduled surgery; US, unscheduled surgery; M, medical; SOFA; OD, organ dysfunction (SOFA score 1–2 points); OF organ failure (SOFA score 3–4 points).

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Table 1.

The departments to which the patients were admitted (%).

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Table 2.

Characteristics of the patients with an ICU LOS of at least 5 days.

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Table 3.

Characteristics of the patients with an ICU LOS of at least 5 days, type of admission to ICU.

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Fig 2.

Number of organ failure on admission and day 3.

Number of patients with n organ failure ad admission (rectangle); Number of patients with n organ failure on day 3 (triangle); ICU Mortality (mean group ± 95% CI) in respect to number of organ failure for 23,795 cases with an ICU length of stay of at least five days.

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Fig 3.

Organ failure on admission and day three of ICU treatment in the ScS-, the US- and the M-patients.

Bars depict the ICU mortality rate of each organ failure (group mean ± 95% CI). Mortality increased with an increasing number of organ failures while the same number of organ failures on day three had a higher mortality rate compared to the day of ICU admission for every type of admission. M patients had higher mortality rates than surgical admitted patients. Lines depict the number of cases with an organ failure. ScS, scheduled surgery; US, unscheduled surgery; M, medical patients; Adm, ICU Admission day; day 3, third day of ICU treatment.

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Fig 4.

Prevalence of Organ dysfunction and failure per organ at admission to ICU and at day 3.

Depicted are the prevalences (mean group ± 95% CI) of organ dysfunction (SOFA score 1–2 points) and organ failure (SOFA score 3–4 points) on admission and on day 3 of ICU in respect to the type of admission in patients with an ICU LOS of at least five days. M-patients had on admission to ICU and on day 3 less heart failure (B) and less coagulation dysfunction (D), but a higher proportion of respiratory (A) and renal failure (C) than the ScS and the US patients. ScS, scheduled surgery; US, unscheduled surgery; M, medical; Adm, admission to ICU; day 3 day 3 of ICU treatment; normal, individual organ SOFA score 0 points; dysfunction, individual organ SOFA score 1–2 points; failure, individual organ SOFA score 3–4 points.

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Table 4.

Multivariate, forward stepwise logistic regression analysis in patients with an ICU length of stay of at least 5 days (n = 23,795), with intensive care unit mortality as the dependent factor.

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Fig 5.

Multivariate, forward stepwise logistic regression analysis with intensive care unit mortality as the dependent factor and OD/OF at day 3.

All data are adjusted to age, gender and organ dysfunction/organ failure at admission. Odds ratio is depicted in a logarithmic plotting (n = 23,795). In organ dysfunction only a significantly increased risk of death is observed in the M-patients with lung dysfunction. The highest risk of death is found in M-patients with cardiovascular or liver failure, as well as in ScS patients with liver or renal failure. In US-patients renal failure was accompanied with the highest risk of death. OR, odds ratio; CI, confidence interval; OD, organ dysfunction; OF, organ failure; CV, cardiovascular; ScS, scheduled surgery; US, unscheduled surgery; M, medical.

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