Fig 1.
PH: Pulmonary hypertension; LHD–PH: PH due to left heart disease; ILD–PH: PH due to interstitial lung disease; PAH: Pulmonary arterial hypertension; CTEPH: Chronic thromboembolic PH.
Fig 2.
Comparison of baseline values of COMF and COTD.
Simultaneous determination of cardiac output by thermodilution (COTD) and Modelflow (COMF) in 50 patients with pre-capillary pulmonary hypertension. (A) The figure describes median (line), 25th to 75th percentile (box), 5th to 95th percentile (whiskers) and the dots represent outliers. The mean values for COTD and COMF were 5.46 ± 1.95 L·min-1 and 6.18 ± 1.95 L·min-1, respectively (p<0.05). (B) Difference between resting COMF and COTD values plotted against their mean. Broken line represents the mean (+ 0.72 L·min-1) and the solid lines the 95% limits of agreement (-1.32 to + 2.76 L·min-1).
Fig 3.
Relationship between COMF and COTD.
COMF determined in 50 patients (98 values) under various conditions (rest, fluid challenge, NO testing and exercise). COMF values were plotted against the corresponding COTD values for CTEPH patients (A) PAH patients (B) and all 50 patients (C). (D) Difference between COMF and COTD values plotted against their mean. In (A), (B) and (C), the broken lines correspond to the lines of equality, solid lines are the mean regression lines and dotted lines delimit the confidence interval of the regression lines. In (D), broken line represents the mean (+ 1.05 L·min-1) and the solid lines the 95% limits of agreement (-1.30 to + 3.40 l.min-1).
Fig 4.
Relationship between COMFcorr. and COTD.
COMFcorr. determined in 26 patients (48 values). (A) For each subject, COMFcorr. values were plotted against the corresponding COTD values. The broken line corresponds to the line of equality, solid line is the mean regression lines and dotted lines delimit the confidence interval of the regression lines. (B) Difference between COMFcorr. and COTD values plotted against their mean. Broken line represents the mean (-0.03 L·min-1) and the solid lines the 95% limits of agreement (-1.23 L·min-1 to +1.17 L·min-1).
Fig 5.
Relationship between COMFcorr. and COTD during exercise.
COMFcorr determined in 6 patients during exercise procedure. (A) For each subject, COMFcorr values were plotted against the corresponding COTD values. The broken line corresponds to the line of equality, solid line is the mean regression lines and dotted lines delimit the confidence interval of the regression lines. (B) Difference between COMFcorr and COTD values plotted against their mean. Broken line represents the mean (-0.15 L·min-1) and the solid lines the 95% limits of agreement (-1.42 l.min-1 to +1.12 L·min-1). (C) For each subject and workload, the increase (Δ) in COMFcorr from rest was plotted against the same corresponding COTD increase (ΔCOTD). The six different targets correspond to the six different patients. The broken line corresponds to the line of equality.
Table 1.
Baseline characteristics of the study population.
Table 2.
Diagnosis and treatment of the PAH population (%).
Table 3.
Diagnosis and treatment of the CTEPH population (%).
Table 4.
Conditions and number of simultaneous COTD and COMF measurements.