Fig 1.
Flow diagram of patient recruitment.
Table 1.
Patient Demographics and Disease Characteristics.
Table 2.
Donor Demographics.
Fig 2.
Clinical response to fecal microbiota transplantation.
(A) Ulcerative colitis disease activity index (UCDAI) scores at transplant (TP) and 1 month (1 Mo) after transplant. (B) Histology scores at transplant and 1 month after transplant. (C) 6-Point UCDAI Scores (Rectal bleeding + Stool Frequency) at baseline (BL), transplant, and after transplant. (D) Fecal calprotectin levels at baseline, transplant, and after transplant. Vertical lines in figures (C) and (D) represent means with standard deviation.
Fig 3.
Engraftment and Stability of fecal microbiota transplantation.
Recipient similarity to (A) recipient baseline and (B) donor baseline are plotted. The (C) DSI sets the second baseline (BL2) similarity to donor to zero and scales the post-transplant similarities. One hundred percent indicates perfect engraftment.
Fig 4.
Pairwise comparisons of recipient samples.
Pairwise comparison were made between recipient samples before and after transplant (BL 2 and WK 1) to all donor's BL2 samples. In patients that demonstrate transplantation, the percent similarity to their donor (dashed lines) increases more than the percent similarity to any other donor (solid lines). Please note that recipients 3 and 5 had the same donor with stool collected at different time points (D3 and D3’).
Table 3.
Clinical Outcomes Compared with Engraftment Scores.
Fig 5.
Shannon diversity index (SDI) comparisons of samples.
There was no significant difference in baseline recipient and donor diversity. (A) There was also no significant difference in diversity at any time point after transplant relative to baseline. (B) Vertical lines represent means with standard deviation.