Table 1.
Demographic details of the children tested.
Table 2.
The percentages of T, CD8+T, NKT-like and NK cells in the blood and BAL of children with bronchiecstasis (BE) and controls.
Data presented as median (q1, q3) unless otherwise indicated. There was a significant increase in the percentage of CD8+T cells in the blood of children with BE compared with control group (p = .010).
Fig 1.
The percentages of T (CD3) and NKT-like (CD3.56) cells expressing granzyme b (GB) and perforin (PER) in the blood of children with BE (grey bars) compared with controls (clear bars).
There was a significant increase in the percentages of T and NKT-like cells expressing granzyme b and perforin in the blood of children with BE compared with controls.
Table 3.
The percentages of T, NKT-like or NK cells expressing granzyme b (GB) and perforin (PER) in the BAL of children with BE compared with controls.
There was no differences in the percentages of T, NKT-like or NK cells expressing granzyme b or perforin in the BAL of children with BE compared with controls (p>0.05 for all).
Fig 2.
The percentages of T (CD3) and NKT-like (CD3.56) and NK cells (CD56) producing IFNγ and TNFα in the blood of children with BE (grey bars) compared with controls (clear bars).
There was a significant increase in the percentages of T cells producing IFNγ and TNFα, NKT-like cells producing IFNγ (trend for TNFα) and NK cells producing IFNγ (trend for TNFα) in the blood of children with BE compared with controls.
Table 4.
The percentages of T, NKT-like or NK cells producing IFNγ and TNFα in the BAL of children with BE compared with controls There was no significant differences in the percentages of T, NKT-like or NK cells producing IFNγ and TNFα in the BAL of children with BE compared with controls (p>0.05 for all).
Fig 3.
The percentages of T (CD3) expressing granzyme b (GB) and perforin (PER) and T cells producing IFNγ and TNFα in the blood of Indigenous children with BE (grey checkered bars) compared with non-Indigenous children with BE (grey bars).
There was a significant increase in the percentages of T cells expressing granzyme b and perforin in the blood of Indigenous children with BE compared with non-Indigenous children with BE. There was a significant increase in the percentage of T cells producing IFNγ (trend for TNFα), in the blood of Indigenous children with BE compared with non-Indigenous children with BE.
Fig 4.
Representative flow cytometry plots of T cells (CD3+CD56) expressing granzyme b and perforin and producing IFNγ and TNFα in the blood of Indigenous children with BE compared with non-Indigenous children withy BE.
There was a significant increase in the expression of granzyme b and perforin in T cells from Indigenous children with BE compared with non-Indigenous children. There was a significant increase in the percentage of T cells producing IFNγ (trend for TNFα) from Indigenous children with BE compared with non-Indigenous children.
Table 5.
Bivariate analysis of correlations between inflammatory/cytotoxic mediators in blood.