Table 1.
Baseline characteristics of autoantibody-positive individuals.
Fig 1.
Synovial expression of mPGES-1, COX-1, COX-2 and 15-PGDH in autoantibody-positive individuals at risk of developing RA.
Panel (A): comparison of individuals with or without arthralgia in general. Panel (B): comparison of individuals with or without arthralgia in the biopsied joint, within the group of individuals with arthralgia only; values expressed as median (IQR). mPGES-1: microsomal prostaglandin E synthase-1; COX: cyclooxygenase, 15-PGDH: 15-hydroxy prostaglandin dehydrogenase.
Table 2.
Correlation analysis of pain scores and expression of PGE2 pathway enzymes in the synovium of autoantibody-positive individuals.
Table 3.
Baseline characteristics of early arthritis patients.
Table 4.
Correlation analysis of pain scores and expression of PGE2 pathway enzymes in the synovium of early arthritis patients.
Table 5.
Correlation analysis of inflammatory markers and expression of PGE2 pathway enzymes in the synovium of early arthritis patients.
Table 6.
Baseline characteristics of early arthritis patients classified as RA, SpA or UA after 2 years of follow-up.
Fig 2.
Baseline synovial expression of PGE2 pathway enzymes of early arthritis patients classified as RA, UA and SpA at 2 years follow-up.
Representative immunohistochemical staining (A), Expression of mPGES-1 (B) and COX-1 (C) is increased in SpA patients. D) A trend towards increased expression of COX-2 is observed in SpA patients; values expressed as median (IQR) on a logaritmic scale; RA: rheumatoid arthritis; UA: unclassified arthritis; SpA: spondyloarthritis; mPGES-1: microsomal prostaglandin E synthase-1; COX: cyclooxygenase; IOD: integrated optical density.
Table 7.
Baseline expression of PGE2 pathway enzymes in the synovium of early arthritis patients classified as UA>UA, UA>RA or RA>RA at baseline>after 2 years of follow-up.
Table 8.
Baseline synovial expression of PGE2 pathway enzymes in different prognostic outcome groups of patients classified as RA after 2 years of follow-up.