Fig 1.
Flow chart of the steps of data collection.
The figure shows the three steps in the data collection: (1) identification of publications which report on the effect of measures of hypercoagulability and the risk of myocardial infarction (MI) or ischaemic stroke (IS) (2) identification of study populations (3) identification of publications with comparable data. Comparable data can be found in the same publication or in two different publications.
Fig 2.
Prothrombotic risk factors and their effect on myocardial infarction and ischemic stroke.
Each point depicts the log odds ratio as a measure of effect of a particular risk factor on the risk of myocardial infarction (x-axis) as well as the effect on the risk of ischaemic stroke (y-axis). The red dashed lines indicate the null effect for either myocardial infarction (vertical line) or ischaemic stroke (horizontal line). The blue diagonal line represents the theoretical line along which all points would cluster when the role of thrombotic factors is similar in the aetiology of myocardial infarction and ischaemic stroke. As an explicative example red dots represent: #312: KAL-C1-INH (RRIS 5.14 e RRMI 2.12). #281: FXIIIA SNP rs3024462 allele (RRIS 1.82 e RRMI 0.49).
Fig 3.
Prothrombotic risk factors with RRR either >1+SE and <1-SE (left) and either > 1+SE and <1-SE (right).
Each point depicts the log odds ratio as a measure of effect of a particular risk factor on the risk of myocardial infarction (x-axis) as well as the effect on the risk of ischaemic stroke (y-axis). The red dashed lines indicate the null effect for either myocardial infarction (vertical line) or ischaemic stroke (horizontal line). The blue diagonal line represents the theoretical line along which all points would cluster when the role of thrombotic factors is similar in the aetiology of myocardial infarction and ischaemic stroke. On the left are depicted RRR>1+SE and RRR<1-SE. on the right RRR>1+2SE. No factors had RRR<1-2SE. Numbers represent the ID of the corresponding marker in Table 1 and S2, S3 and S4 Tables.
Table 1.
Factors that showed a predominant association with ischaemic stroke or myocardial infarction (RRR>1+SE and RRR<1-SE).
Table 2.
Distribution of RRRs greater than 1+1SE and smaller than 1-1SE for different subgroups of population.