Fig 1.
DNA sequence variants identified within the 5’UTR of the Cox-2 gene in 152 dogs.
Base positions upstream of the ATG translation initiation site (position zero) are noted on the left. *The exact base position for the duplicated sequence could not be determined. The sequence variant most commonly found in gray wolves is boxed.
Table 1.
5’UTR Cox-2 variants found in 68 dogs free of renal disease*.
Table 2.
5’UTR Cox-2 variants found in 84 Flat-Coated Retrievers.
Table 3.
5’UTR Cox-2 variants found in 7 Alaskan gray wolves.
Fig 2.
Alignment of DNA sequences upstream of the ATG of the Cox-2 gene from Human, Horse, Cow, Wolf, CanFam3.1 assembly, Mouse and Chicken.
The presumed translation initiation ATG is boxed. A DNA variant (deletion of 12 nucleotides) is observed in CanFam3.1 sequence when compared to other organisms (double headed arrow).