Fig 1.
Flowchart with numbers of eligible and included children.
ASQ3; Ages and Stages Questionnaire, Third Edition, time window 22–26 months corrected age. BSIDIII: Bayley Scales of Infant and Toddler Development, Third Edition, time window 21–30 months corrected age. NDI: Neurodevelopmental Impairment: BSIDIII cognitive score or composite motor score <70, bilateral blindness/deafness or cerebral palsy.
Table 1.
Characteristics of the study sample.
Table 2.
Characteristics of children who failed the ASQ3 or had NDI.
Table 3.
ASQ3 versus NDI with original (<70) and adjusted BSID thresholds (<80 and <85), sensitivity, specificity, negative and positive predictive values.
Fig 2.
Correlation between BSIDIII combined cognitive and composite motor scores and ASQ3 total scores.
R square is 0.417, p<0.001. Incomplete BSID scores due to CP or severe mental impairment were imputed at 50 and incomplete ASQ scores were imputed with 0 points per item without a valid score.
Fig 3.
ROC curve for NDI with BSIDIII threshold< 70 versus ASQ3 total scores.
Area under the curve 96% p<0.0001
Fig 4.
ASQ3 total scores for children with No NDI and children with NDI.
NDI with BSID threshold set at < 70. Incomplete BSIDIII scores due to CP or severe mental impairment were imputed at 50 and incomplete ASQ3 scores were imputed with 0 points per item without a valid score.**** p< 0.0001
Table 4.
ASQ3 failures and the domains for different NDI thresholds.