Fig 1.
Trial profile of the neurodevelopmental follow-up.
The study included 331 pregnant women at different stages of pregnancy but before 34 weeks of gestation. Included mothers were allocated to four different groups based on their pre-gestational BMI and their gestational diabetes status. 1In total 21 mothers dropped out of the study before delivery without giving a reason. The 310 mother-child pairs who remained at delivery constituted the four PREOBE-groups in the present trial. 2During early infancy, two children were excluded due to diagnosed congenital disorder (heart disease and immunodeficiency) and until 6 months, another 88 were lost to follow up giving no reason. 3Five children did not attend to the 6 months Bayley test but came to the test at 18 months.
Table 1.
Baseline and background characteristics of the mother-child pairs who participated in the neurodevelopmental follow up at 6 months of age (n = 215), including group comparisons among the four PREOBE-groups.
Table 2.
Effects of maternal pre-pregnancy overweight, obesity or gestational diabetes on infant’s Bayley scores1 at 6 months of age compared to those born to healthy normoweight pregnant women (controls).
Table 3.
Effects of maternal pre-pregnancy overweight, obesity or gestational diabetes on infant’s Bayley scores1 at 18 months of age compared to those born to healthy normo-weight pregnant women (controls).
Table 4.
Logistic regression models assessing the odds of having the different Bayley scale scores at 6 and 18 months of age above the median.
ORs are presented for infants born to mothers with overweight, obesity and gestational diabetes respectively using infants born to mothers with normal weight and no gestational diabetes as reference.
Table 5.
Raw difference1 in Bayley III scores between 6 and 18 months of age in the four PREOBE-groups.