Fig 1.
Schematic overview of A) experimental design and analyses of B) whole-brain voxel-wise activation sensitivity and of C) reproducibility of regional resting CBF and regional task-induced CBF changes.
Table 1.
Vendor-specific parameters of the pCASL product sequences.
Table 2.
variables of the single-compartment model used for quantification (based on Alsop et al., 2015 [10]).
Fig 2.
whole-brain voxel-wise CBF differences associated with finger tapping compared to rest.
Activation maps are overlaid on a mean T1w scan. T-maps for the two sessions of A) GE and B) Philips sequences are thresholded at t = 3.52, p < .001 (uncorrected). C) shows the F-map depicting differences in activation between pCASL sequences, thresholded at F(2,63) = 7.7, p < .001 (uncorrected).
Table 3.
mean CBF and standard deviations (mL/100g GM/min) in the motor cortex during finger tapping and rest, and respective p-values; and relative CBF increase expressed as a percentage of resting CBF, per sequence per session.
Table 4.
Mean CBF measurements and reproducibility estimates between sessions and sequences for resting CBF (CBFrest), finger tapping CBF (CBFFT) and delta CBF in the primary motor cortex.
Fig 3.
intra- and intersequence intraclass correlation coefficients for CBFrest, CBFFT and delta CBF in the motor cortex.
Error bars denote 95% confidence intervals.
Fig 4.
agreement within and between pCASL sequences for resting CBF and delta CBF.
Bland Altman plots of agreement between the two sessions per sequence (A, B) and between sequences (C) for resting CBF (I) and delta CBF (II) in the primary motor cortex. The solid line indicates the mean difference between sessions, dotted lines the 95% limits of agreement.