Table 1.
Clinical characteristics of our 6 cases (1).
NOAC, Non-vitamin K antagonist oral anticoagulant; mRS, Modified Rankin Scale; M, Male; F, Female; IC, Impaired consciousness; Ri, Rivaroxaban; Ap, Apixaban; ASA, Acetylsalicylic acid; Rt, Right; Lt, Left; Th, Thalamus; SAH, Subarachnoid hemorrhage; SDH, Subdural hemorrhage; Ca, Caudate head hemorrhage; Pu, Putamen; ICH, Intra cerebral hemorrhage.
Table 2.
Clinical characteristics of our 6 cases (2).
BMI, Body mass index; BP, Blood pressure; ICH, Intra cerebral hemorrhage; APTT, Activated partial thromboplastin time; PT-INR, prothrombin time-international normalized ratio; Ccr, Creatinine clearance; NOAC, Non-vitamin K antagonist oral anticoagulant; mRS, Modified Rankin Scale; NIHSS, National Institute of Health Stroke Scale; NSAID, Non-steroidal anti-inflammatory drug; Ap, Apixaban; Wa, Warfarin; Tr, Transferred to the rehabilitation hospital; D, Death; Cd, Changed departments; NE, Not evaluated.
Fig 1.
Brain computed tomography (CT) on admission (left) and 24 h later (right) in Cases 1, 3–6, 1.5 h later (right) in Case 2 who had intracranial hemorrhage during NOAC therapy.
No hematoma expansion is evident in any of the cases.
Table 3.
Characteristics of symptomatic ICH in patients receiving NOACs (1).
mRS, Modified Rankin Scale; NOAC, Non-vitamin K antagonist oral anticoagulant; BP, Blood pressure; ICH, Intracerebral hemorrhage; Cr, Creatinine; eGFR, Estimate glomerular filtration rate; Ccr, Creatinine clearance; PT-INR, Prothrombin time-international normalized ratio; APTT, Activated partial thromboplastin time; M, Male; F, Female; Sub, Subcortical hemorrhage; SDH, Subdural hemorrhage; SAH, Subarachhnoid hemorrhage; Th, Thalamic hemorrhage; Bg, Basal ganglia hemorrhage; NR, Not reported; Da, Dabigatran; Ri, Rivaroxaban; S, small; L, Large; m, Month; w, Week; d, Day; MF, Mechanical fall; HT, Head trauma; BE, Burr-hole evacuation; D, Death; Dh, discharged to home; Tr, Transferred to the rehabilitation hospital.
Table 4.
Characteristics of symptomatic ICH in patients receiving NOACs (2).
mRS, Modified Rankin Scale; NOAC, Non-vitamin K antagonist oral anticoagulant; BP, Blood pressure; ICH, Intracerebral hemorrhage; Cr, Creatinine; eGFR, Estimate glomerular filtration rate; Ccr, Creatinine clearance; PT-INR, Prothrombin time-international normalized ratio; APTT, Activated partial thromboplastin time; M, Male; F, Female; S, Small; Me, Medium; d, day; m, month; y, year; SDH, Subdural hemorrhage; SAH, Subarachhnoid hemorrhage; Th, Thalamic hemorrhage; Pu, Putaminal hemorrhage; Ce, Cerebellar hemorrhage; Bg, Basal ganglia hemorrhage; Ca, Caudate head hemorrhage; Sub, Subcortical hemorrhage; NR, Not reported; Da, Dabigatran; Ri, Rivaroxaban; MF, Mechanical fall; HT, Head trauma; BE, Burr-hole evacuation; VE, Ventricular drainage; D, Death; Dh, discharged to home; Tr, Transferred to the rehabilitation hospital.