Table 1.
Results of a nasopharyngeal carcinoma screening program performed in Cangwu, a high-risk area in China.
Table 2.
Nasopharyngeal EBV DNA load and serum VCA/IgA titers in seropositive high-risk population.
Fig 1.
Relationship of EBV DNA load and DNA amount in the nasopharyngeal swabs.
The swab EBV DNA load showed only a modest correlation with the DNA amount in the nasopharyngeal swabs (Spearman’s correlation coefficient = 0.30, P < 0.001).
Table 3.
Multivariate liner regression for the relation between age, sex, β-globin copy numbers, serum VCA/IgA and nasopharyngeal EBV DNA load.
Fig 2.
EBV load and VCA/IgA titers in males and females.
Nasopharyngeal EBV load and serum VCA/IgA titers by gender and age groups. (a) Mean EBV load in females was higher than that of males by different age groups; EBV load increased with age in both genders. (b) There was no difference in VCA/IgA titers between males and females in different age groups; VCA/IgA titers increased with age in both males and females.
Table 4.
Nasopharyngeal EBV DNA load and serum VCA/IgA titers by gender and age.
Fig 3.
Diagnostic performance of EBV load and VCA/IgA titers.
Cut-off values (COV) and areas under receiver operating characteristic (ROC) curves were calculated to evaluate the diagnostic performance of EBV load and VCA/IgA titers. (a) The optimal COV for EBV load was mean plus 2 standard deviations (i.e. 4.7×105 copies/swab); (b) The best COV for VCA/IgA titers was mean plus standard deviation (i.e. 1:20); (c) The ROC curve indicated that EBV load had a better diagnostic value than VCA/IgA titers; the area under the curve of EBV load was larger than VCA/IgA titers.
Table 5.
Comparison of viral load and VCA/IgA titers between NPC and NPC-free high-risk subjects.
Table 6.
Cut-off values for EBV load and VCA/IgA titers.
Table 7.
Area under the operating characteristics curve.