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Table 1.

The definition of the risk of each bias.

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Fig 1.

Flow Chart of Randomized Controlled Trials that were Evaluated.

From: Moher D, Liberati A, Tetzlaff J, Altman DG, The PRISMA Group (2009). Preferred Reporting Iterns for Systematic Reviews and Meta-Analyses: The PRISMA Statement. PLoS Med 6(6): e1000097. doi:10.1371/journal.pmed1000097 For more information, visit www.prisma-statement.org.

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Table 2.

Main characteristics of studies included.

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Fig 2.

Risk of Bias in the Studies that were included in this Meta-analysis.

(A) Review judgments of authors on each methodological quality item presented as percentages across all studies. (B) Review judgments of authors on each methodological quality item for each included study.

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Fig 3.

Forest Plot for Undetectable HBV DNA when ETV was used as the Control Group.

(A) Forest plot for undetectable HBV DNA based on a fixed-effects model. (B) Forest plot for undetectable HBV DNA based on a random-effects model.

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Fig 4.

Forest Plot for Undetectable HBV DNA when IFN was used as the Control Group.

(A) Forest plot for undetectable HBV DNA based on a random-effects model. (B) Forest plot for undetectable HBV DNA based on a fixed-effects model.

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Fig 5.

Forest Plot for ALT Normalization when ETV was used as the Control Group.

(A) Forest plot for ALT normalization based on a random-effects model. (B) Forest plot for ALT normalization based on a fixed-effects model.

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Fig 6.

Forest Plot for ALT Normalization when IFN was used as the Control Group.

(A) Forest plot for ALT normalization based on a random-effects model. (B) Forest plot for ALT normalization based on a fixed-effects model.

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Fig 7.

Forest Plot for HBeAg Seroconversion when ETV was used as the Control Group.

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Fig 8.

Forest Plot for HBeAg Seroconversion when IFN was used as the Control Group.

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Table 3.

Sensitivity analysis for all outcomes with high heterogeneity.

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Table 4.

Publication bias for all outcomes included.

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