Fig 1.
Flowchart of the study population.
These patients had the classic characteristics of MS populations: F/M sex ratio 2.47 (19,656/7,947); mean age at MS clinical onset 32.8 ± 10.6 years; and 85.5% relapsing-onset MS (23,438/27,408; 195 missing values). As expected, mean age at onset was significantly higher and F/M sex ratio lower for progressive onset MS than for relapsing-onset MS (41.8 ± 10.8 vs. 31.2 ± 9.7 years, t test, p < 10−4, and 1.40 vs. 2.76, Fisher’s exact test, p < 10−4, respectively). MS = Multiple Sclerosis.
Table 1.
Comparison of demographic and clinical characteristics of patients with multiple sclerosis (MS) according to vital status at the end of the study.
Table 2.
Characteristics of the 1569 deaths categorized by underlying cause of death.
Table 3.
Mortality rates and survival probabilities 25 years after MS clinical onset.
Fig 2.
Comparison of the survival in MS patients with the survival of the French general population.
Kaplan-Meier survival estimates according to time from MS clinical onset (years). MS = Multiple Sclerosis.
Table 4.
Overall and subgroup comparisons of mortality between MS patients and the French general population using Standardized Mortality Ratios (SMR estimates with 95% CI, Poisson distribution).