Fig 1.
Consort flow Diagram.
Table 1.
Characteristics and findings in 212 hemodialysis patients studied by hepatic MRI to determine liver iron content (LIC), and assessment of iron biomarkers.
Table 2.
Biochemical markers of iron metabolism in 212 hemodialysis patients studied by hepatic MRI to determine liver iron content (LIC).
Fig 2.
Histogram of liver iron content measured by quantitative MRI in two cohorts of hemodialysis patients treated with different ferritin and transferrin saturation targets for iron repletion.
Table 3.
Correlations between the liver iron concentration determined by MRI and iron biomarkers in 212 hemodialysis patients studied (Spearman rank order correlation test).
Fig 3.
Correlations of liver iron stores studied by quantitative MRI with serum ferritin and the soluble transferrin receptor/ferritin ratio in 212 hemodialysis patients.
Table 4.
Area under the receiver operating characteristics (ROC) curve of iron biomarkers for diagnosis of iron overload (LIC > 50 micromol/g) in 212 hemodialysis patients studied by hepatic MRI.
Table 5.
Optimal threshold values and diagnostic accuracy of iron biomarkers to detect iron overload (LIC > 50 micromol/g), as determined in 212 hemodialysis patients studied by hepatic MRI.
Table 6.
Area under the receiver operating characteristics (ROC) curve, optimal threshold values and diagnostic accuracy of serum ferritin and the serum soluble transferrin receptor/ferritin ratio to detect severe iron overload (LIC > 200 micromol/g) as determined in 212 hemodialysis patients studied by hepatic MRI.
Fig 4.
ROC curves of iron biomarkers for predicting iron overload (LIC > 50 μmol/g) in 212 hemodialysis patients studied by quantitative hepatic MRI.
Fig 5.
ROC curve analysis of serum ferritin for predicting iron overload at a cutoff of LIC > 50 and > 200 μmol/g in the overall cohort of 212 hemodialysis patients studied by quantitative hepatic MRI.
Fig 6.
ROC Curves of ferritin compared to a combination of the eight biomarkers for predicting iron overload (LIC > 50 μmol/g) in 212 hemodialysis patients studied by quantitative hepatic MRI.