Table 1.
Clinical data and details of EEG-fMRI.
Table 2.
Region of increased signal for the contrast: GSWD offset versus GSWD onset (cluster level: p < 0.001 not corrected, voxel level: p < 0.05).
Table 3.
Region of significant difference for the contrast GSWD offset versus rest (cluster level: p < 0.001 not corrected, voxel level: p < 0.05).
Fig 1.
Brain regions showing BOLD signal changes at absence seizures termination.
A. Areas of increased signal for the condition GSWD offset versus GSWD onset. B. Areas of decreased signal for the condition GSWD offset versus rest. Maps are superimposed on the template image MRICro (http://www.mccauslandcenter.sc.edu/mricro/index.html) and are thresholded at p ≤ 0.001 uncorrected for multiple comparisons, with a cluster extent threshold (k) of 10 voxels (p ≤ 0.05). Color bar represents T-values.
Fig 2.
The Dorsolateral prefrontal cortex at absence seizure termination.
Decrease BOLD signal at GSWD termination was observed in 12 patients. Axial sections displaying negative BOLD signal changes in single patients for the contrast GSWD offset versus rest; numbers represent MNI coordinates. Maps are superimposed on the MRICro (http://www.mccauslandcenter.sc.edu/mricro/index.html) template and are thresholded at p ≤ 0.001 uncorrected for multiple comparisons, with a cluster extent threshold (k) of 10 voxels (p ≤ 0.05). Color bar represents T-values.
Fig 3.
A. Shows the mean BOLD time-course of the thalamus (contrast GSWD onset respect to rest: MNI coordinates for ROI: 6–4 2). B. BOLD time course of the PCC (contrast GSWD offset versus GSWD onset coordinates for this ROI was: -10–52 14). C. Shows the BOLD time-course of the frontal ROI (contrast GSWD offset versus rest; MNI coordinates: -34–8 46). In each graph the time ‘0’ represents the onset of the spike and wave discharge.