Table 1.
Respiratory pathogens detected by each Kit.
Fig 1.
Decision tree (algorithm used for Core tests).
(Inf A: Influenza A, Inf B: Influenza B, hRSV: human Respiratory Syncytial Virus, hMPV: human Metapneumovirus, EV + hRV:; Enterovirus + human Rhinovirus, AdV: Adenovirus and hBoV: human Bocavirus).
Table 2.
Viral etiologies identified and bacterial results.
Table 3.
Performances of the four kits for individual Core tests (Inf A, Inf B, hRSV, hMPV, EV + hRV, AdV and hBoV), parainfluenza viruses, Influenza A H1N1pdm 2009 and coronaviruses.
Table 4.
Global comparison of PPV, Sensitivity, NPV, Specificity and Youden's index values between kits for all tests.
Fig 2.
Estimate of detection limit of the different kits.
Inf A H1N1: Influenza A H1N1 (A/Marseille/9410380/2009), Inf A H3N2: Influenza A H3N2 (A/Marseille/4781598/2009), Inf B: Influenza B (B/Marseille/4461097/2008), Inf C: Influenza C (C/Leningrad:232/83), hRSV A and B: human Respiratory Syncytial virus type A (Long) and B (Gb2), hRV: Rhinovirus (MAR2007 3813047), EV Cox B3: Enterovirus (Human Coxsackievirus B3 clinical strain B32679), hPeV: human Parechovirus type 3 (UNK), AdV B: Adenovirus type B (MAR2007 7416184 clinical strain), and hMPV A: human Metapneumovirus type A.
Table 5.
Global comparison of PPV, Sensitivity, NPV, Specificity and Youden's index values between kits for Core tests (Inf A, Inf B, hRSV, hMPV, EV + hRV, AdV and hBoV).