Table 1.
Distribution for input parameters.
Fig 1.
Outputs produced by the LR91 model.
(a) Action potential biomarkers used as model outputs to characterise the model. (b) Action potential time series from 200 runs of the LR1991 model used as design data for the GP emulator.
Fig 2.
Design data and test data obtained from 220 runs of the LR1991 model for eight outputs and six inputs.
Each plot shows combinations of inputs and outputs, with 200 coloured points indicating design data used to fit the emulators, and 20 grey points showing test data used to validate the emulator.
Fig 3.
Validation of APD90 emulator output against test data output.
This plot shows the difference in the mean APD90 predicted by the emulator and APD90 obtained from the simulator for each of the 20 test data. The difference is calibrated as the number of standard deviations, and the red lines indicate ±2 standard deviations.
Fig 4.
(a) Distributions of APD90 resulting from normal distributions of GK when all other maximum conductances were effectively held constant by assigning a mean of 0.5 and a very small variance of 0.0001 in normalised units. GK was assigned a mean value of 0.282 mS cm-2 and variance 0.0014 (blue) 0.0028 (red), 0.0071 (green), 0.0141 (yellow) mS cm-2. (b) Distributions of APD90 obtained from four Monte Carlo analyses, each with 2000 simulator runs, and with GK drawn from distributions with mean value of 0.282 mS cm-2 and variance 0.0014 (blue) 0.0028 (red), 0.0071 (green), 0.0141 (yellow) mS cm-2.
Fig 5.
Mean effects in APD90 emulator.
Mean effect of each of the inputs on APD90 as each input is varied whilst the others are held at their mean value.
Fig 6.
Sensitivity indices in APD90 emulator.
Sensitivity index of each of the inputs on APD90, showing the proportion of total variance that can be attributed to variance in each input.
Table 2.
Emulator characteristics.
Fig 7.
Mean effects in each emulator.
Mean effect of each of the inputs on each output as each input is varied whilst the others are held at their mean value.
Fig 8.
Variance based main effect indices for each emulator.
Main effect index of each emulator (rows) to each input (columns), describing the proportion of the output variance that can be accounted for by variance on the input.
Fig 9.
Sensitivity indices calculated with PLS technique.
Sensitivity index of each emulator (rows) to each input (columns).