Fig 1.
Illustration of the single processing steps used for generation of the problem-specific brain regions in three selected slices.
From top to bottom: MNI reference atlas, infarct distribution map used to exclude voxels lesioned in less than five patients from statistical calculations, p-value map used to exclude voxel with a significance level p≥0.05 from the VOI generation, median mRS values of lesioned and non-lesioned voxels used to define the final VOIs based on the median mRS difference d (VOI1: d > 2, VOI2: 1 < d ≤ 2, VOI3: 0 < d ≤ 1, VOI4: remaining voxels).
Table 1.
Overview of the features used for generation of the twelve SVM models.
The complete Harvard-Oxford cortical brain structure list can be found in S1 Table.
Table 2.
Patient characteristics for the different mRS patient groups.
Table 3.
Quantitative results of the leave-one-out cross evaluation of the twelve SVM models.
Table 4.
Correlation coefficients between the follow-up mRS outcome and the three optional parameters (lesion volume, age, and admission NIHSS), the lesion-based t-score sum, as well as lesion overlap measures of the predefined MNI brain structures and automatically determined problem-specific VOIs.