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Fig 1.

Flowchart of study selection.

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Table 1.

Characteristics of included RCTs comparing cryotherapy versus no treatment or other interventions (1).

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Table 2.

Characteristics of included RCTs comparing cryotherapy versus no treatment or other interventions (2).

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Fig 2.

Effect of oral cryotherapy on the incidence of oral mucositis in patients with hematological malignancies undergoing hematopoietic stem cell transplantation.

RR: risk ratio; CI: confidence interval.

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Fig 3.

Subgroup analysis of the effects of oral cryotherapy on the incidence of oral mucositis in patients with hematological malignancies undergoing hematopoietic stem cell transplantation.

RR: risk ratio; CI: confidence interval.

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Fig 3 Expand

Fig 4.

Effect of oral cryotherapy on the severity of oral mucositis in patients with hematological malignancies undergoing hematopoietic stem cell transplantation.

SMD: standardized mean difference; CI: confidence interval.

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Fig 5.

Effect of oral cryotherapy on the duration of oral mucositis in patients with hematological malignancies undergoing hematopoietic stem cell transplantation.

SMD: standardized mean difference; CI: confidence interval.

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Fig 5 Expand

Fig 6.

Effect of oral cryotherapy on the duration of analgesic use in patients with hematological malignancies undergoing hematopoietic stem cell transplantation.

SMD: standardized mean difference; CI: confidence interval.

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Fig 6 Expand

Fig 7.

Effect of oral cryotherapy on the duration of total parenteral nutrition use in patients with hematological malignancies undergoing hematopoietic stem cell transplantation.

SMD: standardized mean difference; CI: confidence interval.

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Fig 7 Expand

Fig 8.

Effect of oral cryotherapy on the length of hospital stay in patients with hematological malignancies undergoing hematopoietic stem cell transplantation.

SMD: standardized mean difference; CI: confidence interval.

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Fig 8 Expand