Table 1.
Clinical and biochemical characteristics of the subjects involved in the study.
Table 2.
List of differentially expressed circulating miRNAs in the identification group.
Fig 1.
Circulating miRNA concentration of the 9 selected miRNAs, in the whole cohort of 145 individuals.
** = p values<0.05. Data are expressed as arbitrary units (AU).
Fig 2.
Circulating miRNA concentrations of the 9 selected miRNAs, in the whole cohort of 145 individuals, but considering men (M) and women (F) independently.
** = p values<0.05. Data are expressed as arbitrary units (AU). Black, control subjects; Grey, pre-diabetic subjects; White, diabetic patients.
Table 3.
Correlations between circulating miRNA concentrations and metabolic parameters in the study subjects.
Fig 3.
Predicted cellular pathways of the target genes of the significantly altered circulating miRNAs in serum of pre- and/or diabetic patients vs controls.
Only validated miRNAs in the whole cohort were considered.
Fig 4.
Circulating miRNA concentrations of the 9 selected miRNAs identified in the discovery group quantified in the serum of mice fed with normal pellet diet (NPD; n = 5) or with high fat diet (HFD; n = 6).
Data are expressed as arbitrary units (AU). White, NPD mice; Black, HFD.
Table 4.
Correlations between circulating miRNA concentrations and metabolic parameters in mice.