Fig 1.
Each reliving block began with 7 seconds of fixation. Next, participants observed a cue for 2 seconds indicating which memory they were about to relive. Then, after a 1 second fixation screen participants had 5 seconds to read an excerpt taken from their memory journal to facilitate their reliving. Next, participants had 15 seconds of fixation during which time they were instructed to relive their memory. Participants then used a 0–10 sliding scale (which originally appeared at rating 5) to rate how much pain they felt in the scanner. Reliving was followed by 18 seconds of completing visuospatial match to sample trials (9 match to sample trials, each shown for 2 seconds) to avoid carry over effects between memories.
Fig 2.
Self-reported pain ratings for the initial and relived pain.
Fig 3.
Interaction of reliving social pain vs. social neutral, relative to reliving physical pain vs. physical neutral.
Table 1.
Brain regions showing increased activation from the factorial design contrasts: (social pain reliving>social neutral reliving) vs. (physical pain reliving>physical neutral reliving); (physical pain reliving>physical neutral reliving) vs. (social pain reliving>social neutral reliving) vs. (physical pain reliving>physical neutral reliving); social pain reliving versus social neutral reliving; social pain reliving versus physical pain reliving; physical pain reliving versus physical neutral reliving; and physical pain reliving versus social pain reliving.
Fig 4.
A. Direct comparisons of reliving social pain (vs. social neutral). B. Direct comparisons of reliving physical pain (vs. physical neutral). The blank brain indicates that no significant differences were observed in the reliving physical pain (vs. physical neutral) contrast.
Fig 5.
Results from the regression analysis with the difference score in social versus physical pain ratings regressed on the contrast comparing social pain reliving to physical pain reliving.
Greater self-reported pain when reliving social vs. physical pain memories correlated with greater activity in the dACC.
Table 2.
Regression results. Regions that correlate positively with self-reported pain during social vs. physical pain reliving.
Fig 6.
A. Direct comparison of social pain reliving versus physical pain reliving. B. Direct comparison of physical pain reliving versus social pain reliving.
Fig 7.
A. Brain regions whose activation was found to be functionally coupled with DMPFC during social pain reliving (relative to reliving neutral social memories). B. Brain regions whose activation was found to be functionally coupled with IFG during physical pain reliving (relative to reliving neutral physical memories).
Table 3.
Brain regions showing increased functional connectivity with DMPFC during social pain reliving versus social neutral reliving and IFG during physical pain reliving versus physical neutral reliving.