Table 1.
Antibodies used in immunohistochemistry.
Fig 1.
Representative histomorphological features of esophageal mucosal epithelium in pill-induced esophagitis (A-E) and reflux esophagitis (F).
(A) This case shows abundant intraepithelial eosinophil infiltration with eosinophilic microabscess with > 4 eosinophils found in rows. (B) Mixed infiltration of eosinophils and neutrophils is observed within the squamous epithelium. (C) Note intraepithelial pustules, i.e., bullae with scattered neutrophils. (D) Esophageal squamous epithelium shows dilated intercellular spaces (upper part), and extensive vacuolization of squamous epithelial cells (lower part). (E) The subepithelial papillae reach upward to approximately three fourths the epithelial thickness. (F) Reactive atypia (vesicular nucleus and prominent nucleolus) of squamous epithelial cells is present. Magnifications: A, B, F, x400 and C, D, E, x200 (H&E stain).
Table 2.
Differentiation of histomorphological features in squamous epithelium between pill-induced esophagitis and reflux esophagitis groups.
Fig 2.
Immunohistochemical microphotographs of esophageal mucosal tissue in pill-induced esophagitis.
(A) CD3. T lymphocytes are lodged between squamous epithelial cells. (B) CD117. Intraepithelial mast cells are rarely found. (C) & (D) pSTAT3. Diffuse nuclear staining is exhibited in this case (C), but was negative in another case (D). (E) leptin receptor. This picture shows a negative pattern with normally stained basal cells. (F) phospho-mTOR. Membranous staining is noted in only two cells (at the right middle portion, and the left lower end). Magnifications: A, B, E, F, x400 and C, D x200 (immunohistochemical stain).
Table 3.
Comparison of inflammatory infiltrates and eosinophil chemotaxis-associated cells between pill-induced esophagitis and reflux esophagitis groups.
Table 4.
Clinical features of pill-induced esophagitis and reflux esophagitis groups.