Fig 1.
Seventy-two CV negative patients were treated with endobronchial valves at Charité Hospital between 2010 and 2014. In a retrospective study design, complications and development of an atelectasis were evaluated during hospitalization in all 72 patients comprising 32 patients with Standard Medical Care (SMC) (without restriction to bed rest) and 40 patients with Modified Medical Care (MMC) including strict 48 hour bed rest and cough suppression. Complication rate and clinical outcomes comprising pulmonary function, 6MWT and SGRQ during a three month follow up were assessed in 62 out of the 72 valve treated patients. CT scans at 3 months were available for 26 patients in the SMC and 29 patients in the MMC-cohort. CV: collateral ventilation. PFT: pulmonary function test. SGRQ: St. George respiratory questionnaire, TLVR: target lobe volume reduction, 6MWT: six minute walk test.
Table 1.
Demographic characteristics of the study population1.
Table 2.
Complications during hospitalization1.
Fig 2.
Incidence of pneumothorax after ELVR.
Pneumothoraces occurred less often in the Modified Medical Care (MMC) than in the Standard Medical Care (SMC) cohorts.
Table 3.
Complications between discharge after ELVR and three-months follow-up1.
Fig 3.
Radiological changes after ELVR.
A. Atelectasis at chest X-ray on the day of discharge from hospital. B. Patients with a significant TLVR of more than 350ml at 3 months. C. Mean TLVR at 3 months. TLVR: target lobe volume reduction. SMC: Standard Medical Care. MMC: Modified Medical Care.
Fig 4.
Clinical outcomes after three months compared to baseline.
A. Forced expiratory volume in 1 sec (FEV1). B. Residual volume (RV). C. Forced vital capacity (FVC), D. Six Minute walk test (6MWT). E. St. George`s Respiratory Questionnaire (SGRQ). SMC: Standard Medical Care. MMC: Modified Medical Care.
Table 4.
Comparison of clinical outcomes at 3 months after ELVR1 vs. baseline.