Fig 1.
Examples of emphysema in the explanted lungs (H&E stained slides, magnification 200x).
A-E: Emphysematous changes in patients with CF. A = score 1: some emphysematous changes are present next to a scar in <20% of residual lung tissue. B-D = score 2: emphysematous changes in 20–50% of residual lung tissue, next to scar tissue (B) or in the paraseptal region (C and D). E = Score 3: emphysematous changes in >50% of residual lung tissue. F = Emphysema in an explanted lung of a patient with severe COPD, for comparison.
Fig 2.
Pre-transplant axial CT image of CF patient in the work-up to lung transplantation.
Both lungs show substantial apical bullous emphysema (panel A), automatically quantified (panel B) as 17,9% (IN-950). Histopathologically this case was assigned score 2 (20–50% emphysema in the residual lung tissue).
Table 1.
Clinical data of the study population.
Table 2.
Visual grading of structural CF lung disease.
Table 3.
Patient distribution in the histopathologically defined subgroups.
Fig 3.
CT emphysema distribution between the semi-quantitative histopathologic emphysema score subgroups.
CT emphysema is defined as the percentage of lung volume with an attenuation of -950 Houndfield Unit or lower (IN-950).
Fig 4.
Relation between CT Emphysema extent and age.
CT emphysema is defined as the percentage of lung volume with an attenuation of -950 Houndfield Unit or lower (IN-950).
Table 4.
Correlation between lung function parameters and histopathology and quantified CT emphysema score.