Table 1.
Patient demographics, circumstances of overdose and overdose amount.
Table 2.
Overdosage as a multiple of the patient’s usual dose (or factor above maximum licensed dose), decontamination measures and clinical findings.
Fig 1.
Semi-logarithmic plot of sirolimus concentration vs. time in a single case of overdose with 103 mg (Patient 3).
Measurements commenced 24 hours after overdose.
Fig 2.
Total serum cholesterol concentration after overdose.
The first measurement was taken four days after overdose.
Table 3.
Calculated pharmacokinetic parameters t1/2 = half-life, Vd/F = apparent volume of distribution, Cl/F = apparent clearance.