Fig 1.
Study selection dendrogram used for data comparison.
All five studies reported 30-day mortality and relapse in their study cohorts.
Table 1.
UHCMC study patients’ characteristics at initial presentation with TTP-HUS.
Table 2.
Patient outcomes at UHCMC and comparison with relevant studies describing 30-day mortality and relapse.
Fig 2.
Thirty-day mortality and relapse in TTP-HUS.
Thirty-day mortality attributed to TTP-HUS was 2% (1/48); however, overall mortality for patient cohort was 6.7% (4/59) (3 patients died of causes unrelated to TTP-HUS diagnosis (engraftment failure and graft vs. host disease, multi-organ failure due to sepsis and bacteremia, and heart failure due to worsening ejection fraction). Pooled 30-day mortality rate is 16.1% (92–571), p = 0.04. Relapse rate between our entire patient cohort (18.6%) and that of pooled data (14.3%).