Fig 1.
Flow Chart of the present study on cortical thickness in prodromal and dementia stages of Lewy body dementia and Alzheimer's disease.
AD = Alzheimer’s disease; DLB = Dementia with Lewy bodies; MCI = Mild Cognitive Impairment. Prodromal DLB means patients with McKeith's criteria of DLB with cognitive impairment but without dementia. Psychiatric pathologies included two patients with depression, one with bipolar disorder, and one histrionic personality disorder; and one cognitive impairment due to severe sleep apnoea, one vitamin B12 encephalopathy, and one mitochondriopathy for patients with MCI. Other brain pathologies included one Parkinson's disease dementia, one DLB with primary Sjögren's syndrome, one with chronic brain autoimmune encephalitis and one dementia without evolution for more than 10 years, for patients with dementia
Table 1.
Clinical and Demographic Features of Dementia with Lewy bodies patients, Alzheimer’s Disease Patients at the stage of MCI or prodromal and dementia, and healthy elderly controls.
Fig 2.
Cortical thinning patterns in pro-DLB, pro-AD, DLB-d and AD-d compared to healthy older controls (A = Anterior, P = Posterior, FDR = False Discovery Rate).
Table 2.
Location and peak vertex significance of cortical thinning in pro-DLB, DLB-d, pro-AD and AD-d compared to healthy subjects as well as pro-DLB relative to pro-AD, and DLB-d compared to AD-d.
Fig 3.
Patterns of Cortical thinning between Pro-AD and Pro-DLB and between AD-d and DLB-d (A = Anterior, P = Posterior, FDR = False Discovery Rate).
Fig 4.
Correlations between cortical thickness and MMSE for dementia with Lewy bodies (pro-DLB and DLB-d: DLB) and Alzheimer's disease (pro-AD and AD-d: AD) patients (A = Anterior, P = Posterior, FDR = False Discovery Rate).