Table 1.
Characteristics of MESA Stress Study participants.
Fig 1.
Representation of the diurnal cortisol curve describing our summary features of interest.
In our study we specifically used Wakeup, Bedtime, Cortisol awakening response (CAR), Area under the curve (AUC) from 0–16 hours, Early Decline Slope, Late Decline Slope, and Overall Decline Slope.
Table 2.
Characteristics of the stress response genes.
Table 3.
Gene based analysis testing the association between the cortisol features and common variants (minor allele frequency > 0.05) in the stress response genes using SKAT (Method 3).
Fig 2.
LocusZoom plot of the association between all SNPs in the ADRB2 gene region and cortisol features.
Each SNP in the ADRB2 gene region was analyzed by MultiPhen (O’Reilly et al., 2012) stratified by ethnicity. Then the meta-analysis p-values were calculated using Fisher’s probability test and plotted using LocusZoom (Pruim et al., 2010). The linkage disequilibrium is based on the European Americans. This is labeled as Method 2 in the paper.
Table 4.
P-values for the top SNP in ADRB2 gene associated with the seven cortisol features according to multi-phenotype meta analysis (Method 2).