Table 1.
Baseline characteristics of transplant recipients and donors.
Table 2.
Prediction of DGF using KeGFR versus the clinical model.
Fig 1.
Serum creatinine, plasma cystatin C, unadjusted eGFR and kinetic estimated GFR for each patient.
Values for each patient of (A) serum creatinine (sCr), (B) unadjusted estimate of GFR using sCr (eGFRsCr), (C) kinetic estimate of GFR using sCr (KeGFRsCr), (D) plasma cystatin C (pCysC), (E) unadjusted estimate of GFR using pCysC (eGFRpCysC), and (F) kinetic estimate of GFR using pCysC (KeGFRpCysC). Results are stratified for patients developed delayed graft function, i.e. dialysis requirement within 7 days (red) and those who did not (black). Red squares represent patients who were dialysed before the next timepoint. There is no KeGFRpCysC at 0–4h since no 0h pCysC data were available.
Fig 2.
KeGFR versus eGFR, and KeGFRsCr vs. KeGFRpCysC.
A—C: Unadjusted eGFRsCr and KeGFRsCr values stratified for DGF (red) or Non-DGF (black) at 4h (A), 8h (B), and 12h (C). D: Bland-Altman Plot comparing eGFR and KeGFR at 4h (blue triangles), 8h (open squares), and 12h (red circles) after kidney transplantation. Dotted line represents bias (mean difference between parameters); dashed lines represent 95% limits of agreement. E and F: Values for each patient of eGFRpCysC and KeGFRpCysC stratified for DGF or Non-DGF at 8h (E) and 12h (F) G: Bland-Altman Plot comparing eGFR and KeGFR at 8h and 12h after kidney transplantation. H: Bland-Altman Plot comparing KeGFRsCr and KeGFRpCysC at 8h and 12h after kidney transplantation. There was no KeGFRpCysC determined at 4h since no 0h pCysC data were available. #: p ≥ 0.05, * p < 0.05.
Fig 3.
KeGFR prediction of DGF compared with unadjusted eGFR and sCr.
A: estimated kinetic GFR using serum creatinine (KeGFRsCr) compared with serum creatinine (sCr) and unadjusted estimate of GFR using sCr (eGFRsCr). Figures show area under receiver operator characteristic curve (AUC) and 95% confidence intervals for prediction of DGF at 4h (n = 56), 8h (n = 52) and 12h (n = 52). Asterisk (*) denotes p < 0.05 for the comparison with the AUC for sCr at the same time.
Fig 4.
Clinical model enhancement by measured and calculated variables at 12h.
A: serum creatinine (sCr), B: estimated GFR using sCr (KeGFRsCr) C: plasma Cystatin C (pCysC), D: estimated GFR using pCysC (KeGFRpCysC).