Fig 1.
Netrin-1-Based cAMP Signaling Pathway Converging on NFAT.
With the exception of calcineurin, all constituents represented in the figure contain DNA sequence variants associated with advanced AMD at P-values < 1.0 x 10–3. Full gene names exist in the text and at www.ncbi.nlm.nih.gov/gene/. A list of drugs that target CACNA1A, CACNA1C, and calcineurin exists in S1 Table. Diagram was generated with INGENUITY Systems products and is based on a curated resource published by INGENUITY Systems and QIAGEN (Netrin Signaling Pathway, IPA Version: 260639, Content Version: 18030641, Release Date: 6 December 2013).
Fig 2.
Association findings for advanced age-related macular degeneration-SNP relationships in (A) Netrin-1 (NTN1) and (B) Deleted in Colorectal Cancer (DCC) genes.
Points are colored to represent level of linkage disequilibrium (see r2 in legend) with NTN1 rs9899630 and DCC rs8097127 (these two SNPs are represented by violet symbols). SNP genotyping density is represented by the hatch marks at the top of the figure. Positional coordinates of genes and SNPs are labeled on the bottom of the figure. Exons are represented within the gene boundaries with vertical bars. Data are from the AMD Gene Consortium cohort.[12] The figure was generated with LocusZoom[24].
Table 1.
Advanced AMD-associated SNPs in genes encoding Netrin-1 related proteins.