Table 1.
Baseline Demographic and Ocular Characteristics of Study Participants (n = 33).
Fig 1.
CONSORT flow chart.
Fig 2.
Twenty-four-hour IOP pattern measured in CLS (1B) and pneumatonometer eye (1A) (N = 30).
Coefficient of determination between the two eyes was R2 = 0.956. Pneumatonometer data were collected sitting during the diurnal/wake period and supine during the nocturnal/sleep period.
Fig 3.
Example of 30-second plot with the CLS (contact lens sensor) with the patient asleep.
The oscillating signal represents diastolic to systolic variations in IOP due to heart activity, referred to as OPF.
Table 2.
Accuracy of ocular pulse frequency by contact lens sensor in relation to heart rate interval.
Fig 4.
Example of 24-h CLS pattern recorded in a study subject.
The red line represents the wake/sleep (W/S) slope as determined from 1 hour pre- to 1 hour post-sleep.
Fig 5.
Calculation of wake/sleep (W/S) slope as determined from 1 hour pre- to 1 hour post-sleep with CLS (blue).
For the pneumatonometer means (red), actual relative time is not used, but rather one point before, one point closely following and one point after “lights off time”, with a two hour difference between each.