Table 1.
Summary of mathematical notation.
Fig 1.
Schematic of dose-reactive method.
Table 2.
Dose statistics for the first PMF sequence under the non-reactive and reactive± methods.
Fig 2.
Dose-volume histograms (DVHs) for the daily dose distribution at fractions 10, 20, 30 and the final cumulative dose distribution for (ES(0.1),M) (solid curves) and (R±ES(0.1),M) (dashed curves) for the first PMF sequence.
Letters indicate DVHs for tumor (T), left lung (LL), esophagus (E), heart (H) and spinal cord (SC).
Fig 3.
Mean and maximum underdose and overdose by fraction for S and R±ES(0) implementations.
Fig 4.
Mean and maximum underdose and overdose by fraction for ES(0.1) and R±ES(0.1) implementations.
Fig 5.
Mean and maximum underdose and overdose by fraction for ES(0.9) and R±ES(0.9) implementations.
Fig 6.
Mean and maximum underdose and overdose by fraction for R±DLYP implementations.
Fig 7.
Daily delivered dose and target minimum/maximum doses for (ES(0.1),R) and (R±ES(0.1),R).
Where shown, the lower error bar, median and upper error bar for each fraction correspond to the 5th, 50th and 95th percentiles of the appropriate distribution, respectively. On the left-hand plots, the dashed horizontal lines correspond to 2.4Gy and 2.64Gy. The target dose requirements are normalized by 1/(n − i + 1) so as to be comparable to the actual delivered dose of that fraction.