Fig 1.
Bilateral nucleus accumbens seed used in resting-state functional connectivity analysis. MNI coordinates: (-8,12,1), (11,11,1).
Fig 2.
Nucleus Accumbens Seed Functional Connectivity Network of Control > SAD.
Resting-state connectivity for (A) Control group, (B) SAD group, and (C) Control group > SAD group with bilateral nucleus accumbens seed from Fig 1 (Cluster-wise FDR corrected, p < .05; Peak voxel: (MNI Coordinates) (30, 12, -6; p = .001). (vmPFC = ventromedial prefrontal cortex).
Fig 3.
Peak Voxel Axial View for Nucleus Accumbens Seed Functional Connectivity Network of Control > SAD.
Resting-state connectivity for Control group > SAD group with bilateral nucleus accumbens seed from Fig 1 (Cluster-wise FDR corrected, p < .05; Peak voxel: (MNI Coordinates) (30, 12, -6; p = .001). (vmPFC = ventromedial prefrontal cortex).
Fig 4.
Nucleus Accumbens Seed Functional Connectivity Network Z-Scores of Control > SAD.
Mean Fisher transformed correlation values for resting-state connectivity for ventromedial prefrontal cortex cluster from Fig 2C showing significant difference for Control group > SAD group with bilateral nucleus accumbens seed from Fig 1. Peak voxel (MNI coordinates): (30, 12, -6). Bars represent mean connectivity for each group for the ventromedial prefrontal cluster from Fig 2C. One-sample t-test relative to 0: Control: p < .0001; SAD: p = .22. Error bars represent standard errors.
Table 1.
Regions of Significant Differences in Functional Connectivity Between SAD and Control Groups.
Fig 5.
Nucleus Accumbens Seed Functional Connectivity Network of SAD > Control and Z-Scores.
(A) Resting-state connectivity for SAD group > Control group with bilateral nucleus accumbens seed from Fig 1 (Cluster-wise FDR corrected, p < .05; Peak voxel: (MNI Coordinates) (0, -34, 64; p = .006). (B) Mean Fisher transformed correlation values for resting-state connectivity for cluster from Fig 5A showing significant difference for SAD group > Control group with bilateral nucleus accumbens seed from Fig 1. Peak voxel (MNI coordinates): (0, -34, 64). Bars represent the mean connectivity among for each group for the ventromedial prefrontal cluster from Fig 5A. One-sample t-test relative to 0: Control: p < .0001; SAD: p = .07. Error bars represent standard errors.
Fig 6.
Ventromedial Prefrontal Cortex Seed Functional Connectivity Network.
(A) Ventromedial prefrontal cortex seed used in resting-state functional connectivity analysis. MNI coordinates: (-6, 24, -21), (6, 30, -9), (9, 27, -12). (B) Resting-state connectivity for Control group > SAD group with ventromedial prefrontal cortex seed from Fig 6A (Cluster-wise FDR corrected, p < .05). Peak voxel (MNI coordinates): (-12, 20, -20; p < .001). (C) Resting-state connectivity for SAD group > Control group with ventromedial prefrontal cortex seed from Fig 6A (Cluster-wise FDR corrected, p < .05). Peak voxel cluster 1 (MNI coordinates): (6, -42, 60; p = .001). Peak voxel cluster 2 (MNI coordinates: (20, -50, 6; p = .002). Peak voxel cluster 3 (MNI coordinates): (-50, -56, -4; p = .006).
Fig 7.
Peak Voxel Axial View for Ventromedial Prefrontal Cortex Seed Functional Connectivity Network of Control > SAD.
Resting-state connectivity for Control group > SAD group with ventromedial prefrontal cortex seed from Fig 6A (Cluster-wise FDR corrected, p < .05). Peak voxel (MNI coordinates): (-12, 20, -20); p < .001).
Fig 8.
Ventromedial Prefrontal Cortex Seed Functional Connectivity Network Z-Scores of Control > SAD.
Mean Fisher transformed correlation values for resting-state connectivity for clusters from Fig 5B showing significant difference for Control group > SAD group with ventromedial prefrontal cortex seed from Fig 6A. Bars represent the mean connectivity for each group for the medial prefrontal cluster from Fig 6B. Peak voxel Cluster 1 (MNI coordinates): (-12, 20, -20). One-sample t-test relative to 0: Control: p < .0001. SAD p < .0001. Error bars represent standard errors.
Fig 9.
Ventromedial Prefrontal Cortex Seed Functional Connectivity Network Z-Scores of SAD > Control.
Mean Fisher transformed correlation values for resting-state connectivity for clusters from Fig 6C showing significant difference for SAD group > Control group with ventromedial prefrontal cortex seed from Fig 6A. Bars represent the mean connectivity for each group for the clusters from Fig 6C. (A) Peak voxel Cluster 1 (MNI coordinates): (6, -42, 60). One-sample t-test relative to 0: Control: p = .003; SAD: p = .001. (B) Peak voxel Cluster 2 (MNI coordinates): (20, -50, 6). One-sample t-test relative to 0: Control: p < .0001; SAD: p .031. (C) Peak voxel Cluster 3 (MNI coordinates): (-50, -56, -4). One-sample t-test relative to 0: Control: p < .0001; SAD: p = .58. Error bars represent standard errors.