Table 1.
Characteristics of our groups of Zucker rats.
Fig 1.
Time course of plasma glucose (G(t), panel A) insulin (I(t), panel B) and C-peptide (CP(t), panel C) concentrations during 90-min IVGTT in our ZFR group (n = 7, closed circles) and ZLR group (n = 7, open circles).
Values are mean ± SE.
Table 2.
Parameters of insulin action and secretion in ZLR and ZFR groups.
Fig 2.
IVGTT-based mean (±SE) values of model predicted: whole-body insulin sensitivity (SI, panel A); first-phase β-cell responsiveness to glucose stimulus (Φ1, panel B); second-phase β-cell responsiveness to glucose stimulus (Φ2, panel C) and total insulin secretion, for unit of distribution volume (TIS, panel D) in ZLR (open bar) and ZFR (shaded bar) groups.
Measure units are: 10-4·dL·kg-1·min-1/(μU·mL-1) for SI; (pmol/L C-peptide)/(mmol/L glucose) for Φ1; 10-1·min-2·(pmol/L C-peptide)/(mmol/L glucose) for Φ2; and 103·pmol/L for TIS. * p<0.001 and ** p<0.05 in comparing ZFR and ZLR groups.
Fig 3.
Mean (±SD) weighted residual over all our fourteen Zucker rats (7 ZFRs and 7 ZLRs) provided by fitting the CPMM output to C-peptide data.
Fig 4.
Time course of above steady-state insulin secretion rate, SR(t), during 90-min IVGTT in our ZFR group (n = 7, closed circles) and ZLR group (n = 7, open circles).
Values are mean ± SE.