Table 1.
Patients Background (77 patients with 92 HCCs)
.
Fig 1.
The dynamic CT appearance of focal liver injury following SBRT for HCC was classified into 3 types.
A) Type 1 (case 12, 10 months following SBRT). a) Dose distribution b) Plain c) Arterial phase d) Portal phase e) Venous phase. Hypodensity in plain CT and hyperdensity in all enhanced phases. B) Type 2 (case 39, 2 months following SBRT). a) Dose distribution b) Plain c) Arterial phase d) Portal phase e) Venous phase. Hypodensity in the arterial and portal phases and isodensity in the venous phase. C) Type 3 (case 51, 2 months following SBRT). a) Dose distribution b) Plain c) Arterial phase d) Portal phase e) Venous phase. Isodensity in the enhanced phases.
Table 2.
Background of dynamic CT appearance of radiation injury according to previous therapy.
Fig 2.
The time course of dynamic CT appearance of radiation injury to liver according to Child-Pugh class.
Half of type 2 or 3 lesions changed to type 1 at 3–6 months following SBRT, and the change was significant (p = 0.0051). According to the Child–Pugh class, more than half of the type 2 or 3 lesions of Child–Pugh class A changed into type 1 throughout the time course, and this was a significant change (p = 0.0013 at 3–6 months, p = 0.0209 at 6–12 months). On the other hand, the type 2 or 3 lesions of Child–Pugh class B tended to remain unchanged.
Fig 3.
A typical case belonging to Child–Pugh class A that changed from type 3 after 3 months to type 1 after 9 months (case 36).
Dose distribution b) Plain c) Arterial phase d) Portal phase e) Venous phase.
Table 3.
Univariate and Multivariate Analysis between the dynamic CT appearance of radiation injury to the liver and clinical features on Type 3 or Non-Type 3.