Table 1.
Baseline sociodemographic and clinical characteristics of the sample including cases (n = 37) and controls (n = 19).
Table 2.
Differences between cases (n = 37) and controls (n = 19) in metabolic and inflammatory factors.
Table 3.
Brain imaging parameters.
Fig 1.
The associations of serum CCL22 levels with white matter volume (WMV) and diffusion measures within the patient group.
(A) CCL22 level correlated negatively with WMV within the frontal regions of interest (ROIs) (see main text for ROI definitions) bilaterally. Voxels with p < 0.005 (uncorrected, for visualization only; see corrected p-values in Table 4) within frontal ROIs are shown in hot colors on an SPM’s canonical single subject T1 image. Color bar for the t-values depicted in (A) is shown on the right. In (B–C), the FMRIB58 FA mean skeleton is shown in green on a T1 template image. (B) Mean diffusivity and (C) radial diffusivity were positively correlated with CCL22 levels; clusters with p < 0.05 TFCE-corrected for family-wise error rate within unilateral ROIs are shown. On the right of (B) and (C), a color bar shows the corrected p-level for these images. Crosshair in all the images is at x = -12, y = 34, z = 10. In the images, left hemisphere is on the left.
Fig 2.
A positive correlation with serum levels of apolipoprotein A-I and white matter volume in right temporal ROI was observed within patients.
Voxels with p < 0.005 (uncorrected, for visualization only; see corrected p-values in Table 4) within the ROI are shown in hot colors on an SPM’s canonical single subject T1-image. Depicted are the sagittal, coronal, and axial views at x = 18, y = -42, z = 7. At the bottom right, a color plate shows the t-value. Left hemisphere is on the left.
Table 4.
White matter volume and DTI measures within the patient group associating with inflammatory measures.