Fig 1.
Size distribution of TiO2 suspension in NaCl determined by dynamic light scattering.
Table 1.
Titanium dosage in organs and urine performed by ICP-OES.
Fig 2.
Transmission electron microscopy analysis and energy dispersive X ray microanalysis spectrum of TiO2 agglomerates in urine, liver, spleen and kidneys 28 days after intravenous injection.
Fig 3.
HE optical microscopy analysisof TiO2 agglomerates in target organs.
(A) Liver, 1 day after treatment, (B) Liver, 56 days after treatment, (C) Lungs, 1 day after treatment, (D) Lungs, 56 days after treatment, (E) Spleen, 1 day after treatment, (F) Spleen, 56 days after treatment, (F) Kidney, 1 day after treatment, (G) Kidney, 56 days after treatment.
Fig 4.
Data correlation in compartmental model.
Data are represented as blue crosses. Means of data at each time are represented as pink dots. Confidence interval at 95% is represented by a dotted line (Mean ± 1.96 × SD). Results obtained with the compartmental model are represented as a black line.
Fig 5.
Schematic representation of the kinetic models.
Table 2.
Parameters used in the two kinetic models.