Table 1.
Baseline characteristics.
Fig 1.
Survival of patients based on the extent of portal vein invasion.
There was a significant survival difference based on the extent of portal vein invasion. The extent of PVI was classified as none (green), type-I (segmental or sectoral PVI, black), type-II (left and/or right main PVI, blue), and type-III (main trunk invasion or beyond, red). *P = 0.19; †P = 0.01; ‡P < 0.01.
Fig 2.
Survival of patients based on the type of extrahepatic spread.
There was a significant survival difference based on the type of extrahepatic spread. Type of ES was classified as none (black), nodal metastasis only (N, blue) and distant metastasis with or without nodal metastasis (M and/or N, red). *P = 0.84; †P < 0.01.
Table 2.
Factors associated with survival.
Table 3.
Definition and survival of sub-classified Barcelona Clinic Liver Cancer stage C.
Fig 3.
Survival of patients based on the sub-classification.
Patient survival was significantly different based on sub-classification of BCLC stage C patients. Sub-stage C1 includes the patients with portal vein invasion limited to the segmental or sectoral branch and extrahepatic spread limited to the nodal area (black). Sub-stage C2 includes the patients with portal vein invasion that extends beyond the right and/or left main branch without distant metastasis (green), and sub-stage C3 includes the patients with distant metastasis, but portal vein invasion limited to the segmental or sectoral branch (blue). Sub-stage C4 includes the patients with portal vein invasion that extends beyond the right and/or left main branch with distant metastasis (red). *P < 0.01.
Table 4.
Survival by treatment modalities.
Table 5.
Survival by treatment modalities in each sub-stage.