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Fig 1.

Rapid DNA Vaccine Manufacturing in Response to Influenza Pandemic.

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Fig 2.

Consort Flow Diagram.

Number of individuals assessed for eligibility, enrolled and followed up.

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Table 1.

Baseline Characteristics of Participants.

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Table 2.

Frequency of Adverse Events.

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Fig 3.

Immunogenicity.

(A) Hemagglutination Inhibition (HAI) assay with A/Mexico/4482/2009 H1N1 virus (B) Neutralizing antibodies were evaluated by the capacity of sera to prevent infection of 293A cells by replication-incompetent H1-pseudotyped virus. The 80% inhibition serum titers are shown. (C) End-point ELISA titers of H1 A/California/04/2009(H1N1) specific antibodies are shown. Pre-vaccination titers have been subtracted from each plotted value. (D) H1-specific T cell responses are shown as a number of spot forming cells (SFC) per 106 PBMC as measured by ELISpot assay. Geometric means and 95% CI are shown for the study groups.

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