Table 1.
Demographics of the 23 multiplex AAD kindreds from the UK and Norway.
Fig 1.
Graphical representation of parametric linkage results suggestive of linkage (LOD score >2.5) in the multiplex AAD families, assuming a rare dominant model.
Graphical representation of parametric linkage results in the multiplex AAD families, assuming a rare dominant model. The LOD/HLOD score is on the y axis and the cM position is on the x axis. The dotted black line shows the LOD/HLOD threshold of 3.0, taken as convincing evidence of linkage. LOD scores are shown with black lines and HLOD scores with grey lines. Linkage peaks of LOD/HLOD greater than 2.5 were observed on chromosomes 7 (upper left panel), 9 (upper right panel) and 18 (lower left panel).
Fig 2.
Graphical representation of non-parametric linkage results convincing of linkage in the multiplex AAD families.
Graphical representation of non-parametric linkage results in the multiplex AAD families. The LOD score is on the y axis and the cM position is on the x axis. The dotted black line shows the LOD threshold of 3.0, taken as convincing evidence of linkage. Exponential LOD scores are shown with black lines and linear LOD scores with grey lines. A linkage peak of LOD greater than 3.0 was observed on chromosome 6 only.
Table 2.
Association analysis results comparing the 50 AAD family cases to 2706 1958 UK birth cohort controls.
Table 3.
Summary of study results.